Quantitative Deep Sequencing Reveals Dynamic HIV-1 Escape and Large Population Shifts during CCR5 Antagonist Therapy In Vivo

High-throughput sequencing platforms provide an approach for detecting rare HIV-1 variants and documenting more fully quasispecies diversity. We applied this technology to the V3 loop-coding region of env in samples collected from 4 chronically HIV-infected subjects in whom CCR5 antagonist (vicrivir...

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Detalhes bibliográficos
Main Authors: Tsibris, Athe M. N., Korber, Bette, Arnaout, Ramy, Russ, Carsten, Lo, Chien-Chi, Leitner, Thomas, Gaschen, Brian, Theiler, James, Paredes, Roger, Su, Zhaohui, Hughes, Michael D., Gulick, Roy M., Greaves, Wayne, Coakley, Eoin, Flexner, Charles, Nusbaum, Chad, Kuritzkes, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682648/
https://ncbi.nlm.nih.gov/pubmed/19479085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005683
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