PHARMACOKINETIC/PHARMACODYNAMIC MODELING OF THE ANTIRETROVIRAL ACTIVITY OF THE CCR5 ANTAGONIST VICRIVIROC IN TREATMENT EXPERIENCED HIV-INFECTED SUBJECTS (ACTG PROTOCOL 5211)

OBJECTIVE: This sub-study of ACTG Protocol 5211 explored the relationship between antiretroviral effect and plasma concentrations of vicriviroc, an investigational CCR5-antagonist for HIV infection. Eighty-six treatment-experienced subjects failing their current antiretroviral regimens were randomiz...

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Detalhes bibliográficos
Main Authors: Crawford, Keith W., Li, Chonghua, Keung, Anther, Su, Zhaohui, Hughes, Michael D., Greaves, Wayne, Kuritzkes, Daniel, Gulick, Roy, Flexner, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862681/
https://ncbi.nlm.nih.gov/pubmed/20071999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e3181c9caac
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