Evolution of coreceptor utilization to escape CCR5 antagonist therapy

The HIV-1 envelope interacts with coreceptors CCR5 and CXCR4 in a dynamic, multi-step process, its molecular details not clearly delineated. Use of CCR5 antagonists results in tropism shift and therapeutic failure. Here we describe a novel approach using full-length patient-derived gp160 quasispecie...

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發表在:Virology
Main Authors: Zhang, Jie, Gao, Xiang, Martin, John, Rosa, Bruce, Chen, Zheng, Mitreva, Makedonka, Henrich, Timothy, Kuritzkes, Daniel, Ratner, Lee
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4913893/
https://ncbi.nlm.nih.gov/pubmed/27128349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2016.04.010
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