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Evolution of coreceptor utilization to escape CCR5 antagonist therapy
The HIV-1 envelope interacts with coreceptors CCR5 and CXCR4 in a dynamic, multi-step process, its molecular details not clearly delineated. Use of CCR5 antagonists results in tropism shift and therapeutic failure. Here we describe a novel approach using full-length patient-derived gp160 quasispecie...
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| Publicado en: | Virology |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4913893/ https://ncbi.nlm.nih.gov/pubmed/27128349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2016.04.010 |
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