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Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells

Fine tuning of the protein folding environment in subcellular organelles, such as mitochondria, is important for adaptive homeostasis and may participate in human diseases, but the regulators of this process are still largely elusive. Here, we have shown that selective targeting of heat shock protei...

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Autors principals: Siegelin, Markus D., Dohi, Takehiko, Raskett, Christopher M., Orlowski, Gregory M., Powers, Christine M., Gilbert, Candace A., Ross, Alonzo H., Plescia, Janet, Altieri, Dario C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069780/
https://ncbi.nlm.nih.gov/pubmed/21364280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44855
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