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Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis
Evasion of apoptosis is a hallmark of cancer, but the molecular circuitries of this process are not understood. Here we show that survivin, a member of the inhibitor of apoptosis gene family that is overexpressed in cancer, exists in a novel mitochondrial pool in tumor cells. In response to cell dea...
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| Pubblicato in: | J Clin Invest |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC522254/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15489959/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI22222 |
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