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Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis
Evasion of apoptosis is a hallmark of cancer, but the molecular circuitries of this process are not understood. Here we show that survivin, a member of the inhibitor of apoptosis gene family that is overexpressed in cancer, exists in a novel mitochondrial pool in tumor cells. In response to cell dea...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC522254/ https://ncbi.nlm.nih.gov/pubmed/15489959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200422222 |
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