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Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis

Evasion of apoptosis is a hallmark of cancer, but the molecular circuitries of this process are not understood. Here we show that survivin, a member of the inhibitor of apoptosis gene family that is overexpressed in cancer, exists in a novel mitochondrial pool in tumor cells. In response to cell dea...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Dohi, Takehiko, Beltrami, Elena, Wall, Nathan R., Plescia, Janet, Altieri, Dario C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC522254/
https://ncbi.nlm.nih.gov/pubmed/15489959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200422222
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