PRECLINICAL CHARACTERIZATION OF MITOCHONDRIA-TARGETED SMALL MOLECULE Hsp90 INHIBITORS, GAMITRINIBS, IN ADVANCED PROSTATE CANCER

PURPOSE: To characterize the preclinical activity of the first class of combinatorial, mitochondria-targeted, small molecule Hsp90 inhibitors, Gamitrinibs, in models of hormone-refractory, drug-resistant and localized and bone metastatic prostate cancer, in vivo. EXPERIMENTAL DESIGN: Mitochondrial p...

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Detalhes bibliográficos
Main Authors: Kang, Byoung Heon, Siegelin, Markus D., Plescia, Janet, Raskett, Christopher M., Garlick, David S., Dohi, Takehiko, Lian, Jane B., Stein, Gary S., Languino, Lucia R., Altieri, Dario C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948625/
https://ncbi.nlm.nih.gov/pubmed/20876793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1818
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