The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200–dependent pathway in mice

Epithelial tumor cells transit to a mesenchymal state in response to extracellular cues, in a process known as epithelial-to-mesenchymal transition (EMT). The precise nature of these cues has not been fully defined, an important issue given that EMT is an early event in tumor metastasis. Here, we ha...

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Hlavní autoři: Yang, Yanan, Ahn, Young-Ho, Gibbons, Don L., Zang, Yi, Lin, Wei, Thilaganathan, Nishan, Alvarez, Cristina A., Moreira, Daniel C., Creighton, Chad J., Gregory, Philip A., Goodall, Gregory J., Kurie, Jonathan M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069760/
https://ncbi.nlm.nih.gov/pubmed/21403400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42579
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