Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner

The nuclear receptor REV-ERBα is a key negative-feedback regulator of the biological clock. REV-ERBα binds to ROR elements of the Bmal1 (Arntl) promoter and represses Bmal1 transcription. This stabilizing negative loop is important for precise control of the circadian pacemaker. In the present study...

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Autores principales: Meng, Qing Jun, McMaster, Andrew, Beesley, Stephen, Lu, Wei Qun, Gibbs, Julie, Parks, Derek, Collins, Jon, Farrow, Stuart, Donn, Rachelle, Ray, David, Loudon, Andrew
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069549/
https://ncbi.nlm.nih.gov/pubmed/18946026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.035048
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