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A Dominant-negative Gα Mutant That Traps a Stable Rhodopsin-Gα-GTP-βγ Complex

Residues comprising the guanine nucleotide-binding sites of the α subunits of heterotrimeric (large) G-proteins (Gα subunits), as well as the Ras-related (small) G-proteins, are highly conserved. This is especially the case for the phosphate-binding loop (P-loop) where both Gα subunits and Ras-relat...

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Detalhes bibliográficos
Main Authors: Ramachandran, Sekar, Cerione, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069470/
https://ncbi.nlm.nih.gov/pubmed/21285355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.166538
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