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A constitutively active Gα subunit provide insights into the mechanism of G protein activation

The activation of Gα subunits of heterotrimeric G proteins by G protein-coupled receptors (GPCRs) is a critical event underlying a variety of biological responses. Understanding how G proteins are activated will require structural and biochemical analyses of GPCRs complexed to their G protein partne...

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Autors principals: Singh, Garima, Ramachandran, Sekar, Cerione, Richard A.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620018/
https://ncbi.nlm.nih.gov/pubmed/22448927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3001984
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