Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif

Heterotrimeric G proteins are quintessential signalling switches activated by nucleotide exchange on Gα. Although activation is predominantly carried out by G-protein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have emerged as critical signalling molecules and...

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Publicado no:Nat Commun
Main Authors: de Opakua, Alain Ibáñez, Parag-Sharma, Kshitij, DiGiacomo, Vincent, Merino, Nekane, Leyme, Anthony, Marivin, Arthur, Villate, Maider, Nguyen, Lien T., de la Cruz-Morcillo, Miguel Angel, Blanco-Canosa, Juan B., Ramachandran, Sekar, Baillie, George S., Cerione, Richard A., Blanco, Francisco J., Garcia-Marcos, Mikel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454376/
https://ncbi.nlm.nih.gov/pubmed/28516903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15163
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