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Dissociated Gα(GTP) and Gβγ Protein Subunits Are the Major Activated Form of Heterotrimeric Gi/o Proteins

Although most heterotrimeric G proteins are thought to dissociate into Gα and Gβγ subunits upon activation, the evidence in the Gi/o family has long been inconsistent and contradictory. The Gi/o protein family mediates inhibition of cAMP production and regulates the activity of ion channels. On the...

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Detalhes bibliográficos
Main Authors: Bondar, Alexey, Lazar, Josef
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894313/
https://ncbi.nlm.nih.gov/pubmed/24307173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.493643
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