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Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits Gα(i)-GTP and Gβγ
Activation of the G(i) family of heterotrimeric guanine nucleotide–binding proteins (G proteins) releases βγ subunits, which are the major transducers of chemotactic G protein–coupled receptor (GPCR)–dependent cell migration. The small molecule 12155 binds directly to Gβγ and activates Gβγ signaling...
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| Publicado en: | Sci Signal |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6364554/ https://ncbi.nlm.nih.gov/pubmed/26905427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aad8163 |
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