Methylsulfonylnitrobenzoates, a New Class of Irreversible Inhibitors of the Interaction of the Thyroid Hormone Receptor and Its Obligate Coactivators That Functionally Antagonizes Thyroid Hormone

Thyroid hormone receptors (TRs) are members of the nuclear hormone receptor (NR) superfamily and regulate development, growth, and metabolism. Upon binding thyroid hormone, TR undergoes a conformational change that allows the release of corepressors and the recruitment of coactivators, which in turn...

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Bibliografski detalji
Glavni autori: Hwang, Jong Yeon, Huang, Wenwei, Arnold, Leggy A., Huang, Ruili, Attia, Ramy R., Connelly, Michele, Wichterman, Jennifer, Zhu, Fangyi, Augustinaite, Indre, Austin, Christopher P., Inglese, James, Johnson, Ronald L., Guy, R. Kiplin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Gene Regulation
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069392/
https://ncbi.nlm.nih.gov/pubmed/21321127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.200436
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