Distamycin A and tallimustine inhibit TBP binding and basal in vitro transcription.

The antibiotic distamycin A is a DNA minor groove binding drug (MGB) that recognizes a stretch of at least four ATs. The alkylating benzoyl mustard derivative tallimustine (FCE 24517) has powerful anti-tumor activity. Using the electrophoretic mobility shift assay (EMSA) we determined that both comp...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Bellorini, M, Moncollin, V, D'Incalci, M, Mongelli, N, Mantovani, R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1995
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306918/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7784168/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.10.1657
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