Distamycin A and tallimustine inhibit TBP binding and basal in vitro transcription.
The antibiotic distamycin A is a DNA minor groove binding drug (MGB) that recognizes a stretch of at least four ATs. The alkylating benzoyl mustard derivative tallimustine (FCE 24517) has powerful anti-tumor activity. Using the electrophoretic mobility shift assay (EMSA) we determined that both comp...
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| Udgivet i: | Nucleic Acids Res |
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| Principais autores: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
1995
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| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306918/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7784168/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.10.1657 |
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