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Distamycin A modulates the sequence specificity of DNA alkylation by duocarmycin A

Duocarmycin A (Duo) normally alkylates adenine N3 at the 3′ end of A+T-rich sequences in DNA. The efficient adenine alkylation by Duo is achieved by its monomeric binding to the DNA minor groove. The addition of another minor groove binder, distamycin A (Dist), dramatically modulates the site of DNA...

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Detalhes bibliográficos
Main Authors: Sugiyama, Hiroshi, Lian, Chenyang, Isomura, Mariko, Saito, Isao, Wang, Andrew H.-J.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1996
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC26145/
https://ncbi.nlm.nih.gov/pubmed/8962064
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