Distamycin A modulates the sequence specificity of DNA alkylation by duocarmycin A

Duocarmycin A (Duo) normally alkylates adenine N3 at the 3′ end of A+T-rich sequences in DNA. The efficient adenine alkylation by Duo is achieved by its monomeric binding to the DNA minor groove. The addition of another minor groove binder, distamycin A (Dist), dramatically modulates the site of DNA...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Sugiyama, Hiroshi, Lian, Chenyang, Isomura, Mariko, Saito, Isao, Wang, Andrew H.-J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26145/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8962064/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.25.14405
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