Unexpected Syntheses of seco-Cyclopropyltetrahydroquinolines >From a Radical 5-Exo-Trig Cyclization Reaction: Analogs of CC-1065 and the Duocarmycins

Analogs of the seco-cyclopyrroloindoline (seco-CPI), the DNA alkylation pharmacophore of CC-1065 and the duocarmycins, can be prepared through a 5-exo-trig radical cyclization of a free radical and a 3-chloro-2-allylic moiety. This manuscript reports an unexpected discovery that, depending on the st...

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Библиографические подробности

Главные авторы:	Moses Lee, LuAnne McNulty, Brian Lingerfelt, Heather Townes, Lori Forrest, Hari Pati
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2004-02-01
Серии:	Molecules
Предметы:	seco-Cyclopropyltetrahydroquinoline CC-1065 duocarmycins (chloromethyl)furano[e]indoline (chloromethyl)furano[f]tetrahydroquinoline.
Online-ссылка:	http://www.mdpi.com/1420-3049/9/3/125/
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