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Distamycin A and tallimustine inhibit TBP binding and basal in vitro transcription.

The antibiotic distamycin A is a DNA minor groove binding drug (MGB) that recognizes a stretch of at least four ATs. The alkylating benzoyl mustard derivative tallimustine (FCE 24517) has powerful anti-tumor activity. Using the electrophoretic mobility shift assay (EMSA) we determined that both comp...

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Hlavní autoři: Bellorini, M, Moncollin, V, D'Incalci, M, Mongelli, N, Mantovani, R
Médium: Artigo
Jazyk:Inglês
Vydáno: 1995
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC306918/
https://ncbi.nlm.nih.gov/pubmed/7784168
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