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Distamycin A and tallimustine inhibit TBP binding and basal in vitro transcription.
The antibiotic distamycin A is a DNA minor groove binding drug (MGB) that recognizes a stretch of at least four ATs. The alkylating benzoyl mustard derivative tallimustine (FCE 24517) has powerful anti-tumor activity. Using the electrophoretic mobility shift assay (EMSA) we determined that both comp...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
1995
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC306918/ https://ncbi.nlm.nih.gov/pubmed/7784168 |
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