A Trimeric, V2-Deleted HIV-1 Envelope Glycoprotein Vaccine Elicits Potent Neutralizing Antibodies but Limited Breadth of Neutralization in Human Volunteers

Background. A key missing element in the development of a successful human immunodeficiency virus (HIV) vaccine is an immunogen that can generate broadly cross-neutralizing antibodies against primary isolates of the virus. Methods. This phase 1 clinical trial employed a DNA prime and subunit envelop...

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Autors principals: Spearman, Paul, Lally, Michelle A., Elizaga, Marnie, Montefiori, David, Tomaras, Georgia D., McElrath, M. Juliana, Hural, John, De Rosa, Stephen C., Sato, Alicia, Huang, Yunda, Frey, Sharon E., Sato, Paul, Donnelly, John, Barnett, Susan, Corey, Lawrence J.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2011
Matèries:
Major Articles and Brief Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068023/
https://ncbi.nlm.nih.gov/pubmed/21451004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiq175
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