A Trimeric, V2-Deleted HIV-1 Envelope Glycoprotein Vaccine Elicits Potent Neutralizing Antibodies but Limited Breadth of Neutralization in Human Volunteers

Background. A key missing element in the development of a successful human immunodeficiency virus (HIV) vaccine is an immunogen that can generate broadly cross-neutralizing antibodies against primary isolates of the virus. Methods. This phase 1 clinical trial employed a DNA prime and subunit envelop...

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Detalhes bibliográficos
Main Authors: Spearman, Paul, Lally, Michelle A., Elizaga, Marnie, Montefiori, David, Tomaras, Georgia D., McElrath, M. Juliana, Hural, John, De Rosa, Stephen C., Sato, Alicia, Huang, Yunda, Frey, Sharon E., Sato, Paul, Donnelly, John, Barnett, Susan, Corey, Lawrence J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068023/
https://ncbi.nlm.nih.gov/pubmed/21451004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiq175
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