A Trimeric, V2-Deleted HIV-1 Envelope Glycoprotein Vaccine Elicits Potent Neutralizing Antibodies but Limited Breadth of Neutralization in Human Volunteers

Background. A key missing element in the development of a successful human immunodeficiency virus (HIV) vaccine is an immunogen that can generate broadly cross-neutralizing antibodies against primary isolates of the virus. Methods. This phase 1 clinical trial employed a DNA prime and subunit envelop...

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書誌詳細
主要な著者: Spearman, Paul, Lally, Michelle A., Elizaga, Marnie, Montefiori, David, Tomaras, Georgia D., McElrath, M. Juliana, Hural, John, De Rosa, Stephen C., Sato, Alicia, Huang, Yunda, Frey, Sharon E., Sato, Paul, Donnelly, John, Barnett, Susan, Corey, Lawrence J.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2011
主題:
Major Articles and Brief Reports
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068023/
https://ncbi.nlm.nih.gov/pubmed/21451004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiq175
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