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TIA1 Prevents Skipping of a Critical Exon Associated with Spinal Muscular Atrophy

Prevention of skipping of exon 7 during pre-mRNA splicing of Survival Motor Neuron 2 (SMN2) holds the promise for cure of spinal muscular atrophy (SMA), a leading genetic cause of infant mortality. Here, we report T-cell-restricted intracellular antigen 1 (TIA1) and TIA1-related (TIAR) proteins as i...

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Détails bibliographiques
Auteurs principaux: Singh, Natalia N., Seo, Joonbae, Ottesen, Eric W., Shishimorova, Maria, Bhattacharya, Dhruva, Singh, Ravindra N.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2011
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067828/
https://ncbi.nlm.nih.gov/pubmed/21189287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00945-10
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