A Conserved Determinant in the V1 Loop of HIV-1 Modulates the V3 Loop To Prime Low CD4 Use and Macrophage Infection

The CD4 binding site (CD4bs) on the HIV-1 envelope plays a major role in determining the capacity of R5 viruses to infect primary macrophages. Thus, envelope determinants within or proximal to the CD4bs have been shown to control the use of low CD4 levels on macrophages for infection. These residues...

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Main Authors: Musich, Thomas, Peters, Paul J., Duenas-Decamp, Maria José, Gonzalez-Perez, Maria Paz, Robinson, James, Zolla-Pazner, Susan, Ball, Jonathan K., Luzuriaga, Katherine, Clapham, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067776/
https://ncbi.nlm.nih.gov/pubmed/21159865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02187-10
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