Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations

The conformation of HIV-1 envelope (Env) glycoprotein trimers is key in ensuring protection against waves of neutralizing antibodies generated during infection, while maintaining sufficient exposure of the CD4 binding site (CD4bs) for viral entry. The CD4 binding loop on Env is an early contact site...

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Vydáno v:PLoS Pathog
Hlavní autoři: Duenas-Decamp, Maria, Jiang, Li, Bolon, Daniel, Clapham, Paul R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098743/
https://ncbi.nlm.nih.gov/pubmed/27820858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005988
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