Dose-Dependent Activity of Pyrazinamide in Animal Models of Intracellular and Extracellular Tuberculosis Infections

Recent in vitro pharmacokinetic data suggest that the currently recommended dose of pyrazinamide may be suboptimal for killing intracellular bacilli in humans. We evaluated a range of pyrazinamide doses against intracellular and extracellular Mycobacterium tuberculosis in chronically infected mice a...

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Hlavní autoři: Ahmad, Zahoor, Fraig, Mostafa M., Bisson, Gregory P., Nuermberger, Eric L., Grosset, Jacques H., Karakousis, Petros C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2011
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067197/
https://ncbi.nlm.nih.gov/pubmed/21282447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01524-10
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