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Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer’s disease brain
The Beclin-1 protein is essential for the initiation of autophagy and recent studies suggest this function may be compromised in Alzheimer’s disease (AD). In addition, in vitro studies have supported a loss of function of Beclin-1 due to proteolytic modification by caspases. In the present study we...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3066274/ https://ncbi.nlm.nih.gov/pubmed/21081164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2010.11.003 |
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