Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

Autophagy and apoptosis are two important and interconnected stress-response mechanisms. However, the molecular interplay between these two pathways is not fully understood. To study the fate and function of autophagic proteins at the onset of apoptosis, we used a cellular model system in which auto...

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Hlavní autoři: Wirawan, E, Vande Walle, L, Kersse, K, Cornelis, S, Claerhout, S, Vanoverberghe, I, Roelandt, R, De Rycke, R, Verspurten, J, Declercq, W, Agostinis, P, Vanden Berghe, T, Lippens, S, Vandenabeele, P
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032505/
https://ncbi.nlm.nih.gov/pubmed/21364619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2009.16
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