Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes

The aspartate-specific cysteine protease caspase-1 is activated by the inflammasomes and is responsible for the proteolytic maturation of the cytokines IL-1β and IL-18 during infection and inflammation. To discover new caspase-1 substrates, we made use of a proteome-wide gel-free differential peptid...

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Detalhes bibliográficos
Main Authors: Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi, Van Damme, Petra, Vanden Berghe, Tom, Vanoverberghe, Isabel, Vandekerckhove, Joël, Vandenabeele, Peter, Gevaert, Kris, Núñez, Gabriel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596343/
https://ncbi.nlm.nih.gov/pubmed/18667412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M800132-MCP200
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