Proteome-wide Substrate Analysis Indicates Substrate Exclusion as a Mechanism to Generate Caspase-7 Versus Caspase-3 Specificity

Caspase-3 and -7 are considered functionally redundant proteases with similar proteolytic specificities. We performed a proteome-wide screen on a mouse macrophage lysate using the N-terminal combined fractional diagonal chromatography technology and identified 46 shared, three caspase-3-specific, an...

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Autores principales: Demon, Dieter, Van Damme, Petra, Berghe, Tom Vanden, Deceuninck, Annelies, Van Durme, Joost, Verspurten, Jelle, Helsens, Kenny, Impens, Francis, Wejda, Magdalena, Schymkowitz, Joost, Rousseau, Frederic, Madder, Annemieke, Vandekerckhove, Joël, Declercq, Wim, Gevaert, Kris, Vandenabeele, Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2009
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2816020/
https://ncbi.nlm.nih.gov/pubmed/19759058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M900310-MCP200
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