Proteome-wide Substrate Analysis Indicates Substrate Exclusion as a Mechanism to Generate Caspase-7 Versus Caspase-3 Specificity

Caspase-3 and -7 are considered functionally redundant proteases with similar proteolytic specificities. We performed a proteome-wide screen on a mouse macrophage lysate using the N-terminal combined fractional diagonal chromatography technology and identified 46 shared, three caspase-3-specific, an...

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Detalhes bibliográficos
Main Authors: Demon, Dieter, Van Damme, Petra, Berghe, Tom Vanden, Deceuninck, Annelies, Van Durme, Joost, Verspurten, Jelle, Helsens, Kenny, Impens, Francis, Wejda, Magdalena, Schymkowitz, Joost, Rousseau, Frederic, Madder, Annemieke, Vandekerckhove, Joël, Declercq, Wim, Gevaert, Kris, Vandenabeele, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2816020/
https://ncbi.nlm.nih.gov/pubmed/19759058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M900310-MCP200
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