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Enzymatic Blockade of the Ubiquitin-Proteasome Pathway
Ubiquitin-dependent processes control much of cellular physiology. We show that expression of a highly active, Epstein-Barr virus-derived deubiquitylating enzyme (EBV-DUB) blocks proteasomal degradation of cytosolic and ER-derived proteins by preemptive removal of ubiquitin from proteasome substrate...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3066133/ https://ncbi.nlm.nih.gov/pubmed/21468303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000605 |
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