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Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier

The ubiquitin (Ub)-related modifier Urm1 functions as a sulfur carrier in tRNA thiolation by means of a mechanism that requires the formation of a thiocarboxylate at the C-terminal glycine residue of Urm1. However, whether Urm1 plays an additional role as a Ub-like protein modifier remains unclear....

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Detalhes bibliográficos
Main Authors: Van der Veen, Annemarthe G., Schorpp, Kenji, Schlieker, Christian, Buti, Ludovico, Damon, Jadyn R., Spooner, Eric, Ploegh, Hidde L., Jentsch, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033243/
https://ncbi.nlm.nih.gov/pubmed/21209336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014402108
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