Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host

Type I strains of Helicobacter pylori (Hp) possess a pathogenicity island, cag, that encodes the effector protein cytotoxin-associated gene A (CagA) and a type four secretion system. After translocation into the host cell, CagA affects cell shape, increases cell motility, abrogates junctional activi...

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Bibliographic Details
Main Authors: Buti, Ludovico, Spooner, Eric, Van der Veen, Annemarthe G., Rappuoli, Rino, Covacci, Antonello, Ploegh, Hidde L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107298/
https://ncbi.nlm.nih.gov/pubmed/21562218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106200108
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