The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16α-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) expression and protect the body from harmful chemicals. In this study, we demonstrate that PXR is activated by the toxic bile acid lithoch...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Staudinger, Jeff L., Goodwin, Bryan, Jones, Stacey A., Hawkins-Brown, Diane, MacKenzie, Kathleen I., LaTour, Anne, Liu, Yaping, Klaassen, Curtis D., Brown, Kathleen K., Reinhard, John, Willson, Timothy M., Koller, Beverly H., Kliewer, Steven A.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC30660/
https://ncbi.nlm.nih.gov/pubmed/11248085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051551698
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker