The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16α-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) expression and protect the body from harmful chemicals. In this study, we demonstrate that PXR is activated by the toxic bile acid lithoch...

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Detalhes bibliográficos
Main Authors: Staudinger, Jeff L., Goodwin, Bryan, Jones, Stacey A., Hawkins-Brown, Diane, MacKenzie, Kathleen I., LaTour, Anne, Liu, Yaping, Klaassen, Curtis D., Brown, Kathleen K., Reinhard, John, Willson, Timothy M., Koller, Beverly H., Kliewer, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC30660/
https://ncbi.nlm.nih.gov/pubmed/11248085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051551698
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