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Nuclear receptor PXR: discovery of a pharmaceutical anti-target
Transcriptional induction of the gene encoding cytochrome P450 3A oxygenase (CYP3A) causes a prominent class of dangerous drug-drug interactions wherein one drug accelerates the metabolism of another. In our 1998 JCI paper, we reported the cloning of the human nuclear receptor PXR and demonstrated t...
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| Published in: | J Clin Invest |
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| Main Author: | |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Clinical Investigation
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4409023/ https://ncbi.nlm.nih.gov/pubmed/25831443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81244 |
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