Design of a novel nucleoside analog as potent inhibitor of the NAD(+) dependent deacetylase, SIRT2

Sirtuins (class III histone deacetylase) are evolutionarily conserved NAD(+)-dependent enzymes that catalyze the deacetylation of acetyl-lysine residues of histones and other target proteins. Because of their associations in various pathophysiological conditions, the identification of small molecule...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sivaraman, Padavattan, Mattegunta, Suresh, Subbaraju, Gottumukkala V., Satyanarayana, Chava, Padmanabhan, Balasundaram
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer Netherlands 2011
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065595/
https://ncbi.nlm.nih.gov/pubmed/22132052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11693-011-9069-4
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