Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca(2+) fluxes in oxidative cell death

Oxidative DNA damage to cells activates poly(ADP-ribose)polymerase-1 (PARP-1) and the poly(ADP-ribose) formed is rapidly degraded to ADP-ribose by poly(ADP-ribose)glycohydrolase (PARG). Here we show that PARP-1 and PARG control extracellular Ca(2+) fluxes through melastatin-like transient receptor p...

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Bibliografske podrobnosti
Main Authors: Blenn, C., Wyrsch, P., Bader, J., Bollhalder, M., Althaus, Felix R.
Format: Artigo
Jezik:Inglês
Izdano: SP Birkhäuser Verlag Basel 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064896/
https://ncbi.nlm.nih.gov/pubmed/20878536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-010-0533-1
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