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Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca(2+) fluxes in oxidative cell death
Oxidative DNA damage to cells activates poly(ADP-ribose)polymerase-1 (PARP-1) and the poly(ADP-ribose) formed is rapidly degraded to ADP-ribose by poly(ADP-ribose)glycohydrolase (PARG). Here we show that PARP-1 and PARG control extracellular Ca(2+) fluxes through melastatin-like transient receptor p...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
SP Birkhäuser Verlag Basel
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3064896/ https://ncbi.nlm.nih.gov/pubmed/20878536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-010-0533-1 |
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