Antihypertensive therapy increases tetrahydrobiopterin levels and NO/cGMP signaling in small arteries of angiotensin II-infused hypertensive rats

We previously reported that small mesenteric arteries from hypertensive rats have increased NOS-derived H(2)O(2) and reduced NO/cGMP signaling. We hypothesized that antihypertensive therapy lowers blood pressure through a tetrahydrobiopterin (BH(4))-dependent mechanism restoring NO/cGMP signaling an...

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Detalhes bibliográficos
Main Authors: Kang, Kyu-Tae, Sullivan, Jennifer C., Spradley, Frank T., d'Uscio, Livius V., Katusic, Zvonimir S., Pollock, Jennifer S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Vascular Biology and Microcirculation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064310/
https://ncbi.nlm.nih.gov/pubmed/21148769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00393.2010
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