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Erythropoietin increases endothelial biosynthesis of tetrahydrobiopterin by activation of protein kinase Bα/Akt1

Tetrahydrobiopterin (BH(4)) is an essential cofactor required for enzymatic activity of endothelial nitric oxide synthase (eNOS). Recently, it has been shown that vascular protective effects of erythropoietin (EPO) are dependent on activation of eNOS. Therefore, our objective was to characterize the...

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Bibliografiske detaljer
Main Authors: d’Uscio, Livius V., Katusic, Zvonimir S.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646900/
https://ncbi.nlm.nih.gov/pubmed/18519842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.108.114041
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