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Erythropoietin increases endothelial biosynthesis of tetrahydrobiopterin by activation of protein kinase Bα/Akt1
Tetrahydrobiopterin (BH(4)) is an essential cofactor required for enzymatic activity of endothelial nitric oxide synthase (eNOS). Recently, it has been shown that vascular protective effects of erythropoietin (EPO) are dependent on activation of eNOS. Therefore, our objective was to characterize the...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646900/ https://ncbi.nlm.nih.gov/pubmed/18519842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.108.114041 |
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