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Erythropoietin increases endothelial biosynthesis of tetrahydrobiopterin by activation of protein kinase Bα/Akt1

Tetrahydrobiopterin (BH(4)) is an essential cofactor required for enzymatic activity of endothelial nitric oxide synthase (eNOS). Recently, it has been shown that vascular protective effects of erythropoietin (EPO) are dependent on activation of eNOS. Therefore, our objective was to characterize the...

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書誌詳細
主要な著者: d’Uscio, Livius V., Katusic, Zvonimir S.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646900/
https://ncbi.nlm.nih.gov/pubmed/18519842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.108.114041
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