Muscle-specific overexpression of NCOAT(GK), splice variant of O-GlcNAcase, induces skeletal muscle atrophy

The protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification plays an important role in skeletal muscle development and physiological function. In this study, bitransgenic mice were generated that overexpressed NCOAT(GK), an O-GlcNAcase-inactive spliced variant of the O-GlcNAcase gene, specifi...

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Detalhes bibliográficos
Main Authors: Huang, Ping, Ho, Shiuh-Rong, Wang, Kai, Roessler, Bryan C., Zhang, Fengxue, Hu, Yong, Bowe, Damon B., Kudlow, Jeffrey E., Paterson, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Muscle Cell Biology and Cell Motility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063975/
https://ncbi.nlm.nih.gov/pubmed/21178104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00124.2010
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