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Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis
Although focal adhesion kinase (FAK) is typically considered upstream of Akt, extracellular pressure stimulates cancer cell adhesion via Akt-dependent FAK activation. How Akt regulates FAK is unknown. We studied Akt-FAK interaction in colon cancer cells under 15 mmHg increased extracellular pressure...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Physiological Society
2011
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3063963/ https://ncbi.nlm.nih.gov/pubmed/21209368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00377.2010 |
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