Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis

Although focal adhesion kinase (FAK) is typically considered upstream of Akt, extracellular pressure stimulates cancer cell adhesion via Akt-dependent FAK activation. How Akt regulates FAK is unknown. We studied Akt-FAK interaction in colon cancer cells under 15 mmHg increased extracellular pressure...

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Autores principales: Wang, Shouye, Basson, Marc D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2011
Materias:
Receptors and Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063963/
https://ncbi.nlm.nih.gov/pubmed/21209368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00377.2010
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