14β-O-Cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity

14-O-cinnamoyl esters of naltrexone (6) were synthesised and evaluated in isolated tissue assays in vitro and in vivo in mouse antinociceptive assays. Their predominant opioid receptor activity was mu receptor (MOR) antagonism but the unsubstituted cinnamoyl derivative (6a) and the p-methylcinnamoyl...

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Main Authors: Moynihan, H., Jales, A.R., Greedy, B.M., Rennison, D., Broadbear, J.H., Purington, L., Traynor, J.R., Woods, J.H., Lewis, J.W, Husbands, S.M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063885/
https://ncbi.nlm.nih.gov/pubmed/19253983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8012272
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