Rhesus TRIM5α Disrupts the HIV-1 Capsid at the Inter­Hexamer Interfaces

TRIM proteins play important roles in the innate immune defense against retroviral infection, including human immunodeficiency virus type-1 (HIV-1). Rhesus macaque TRIM5α (TRIM5α(rh)) targets the HIV-1 capsid and blocks infection at an early post-entry stage, prior to reverse transcription. Studies...

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Main Authors: Zhao, Gongpu, Ke, Danxia, Vu, Thomas, Ahn, Jinwoo, Shah, Vaibhav B., Yang, Ruifeng, Aiken, Christopher, Charlton, Lisa M., Gronenborn, Angela M., Zhang, Peijun
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063768/
https://ncbi.nlm.nih.gov/pubmed/21455494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002009
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