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Critical Role of Shp2 in Tumor Growth Involving Regulation of c-Myc
Activating mutants of Shp2 protein tyrosine phosphatase, encoded by the PTPN11 gene, are linked to leukemia. In solid tumors, however, PTPN11 mutations occur at low frequencies, while the wild-type Shp2 is activated by protein tyrosine kinases (PTKs) in cancer cells and mediates PTK signaling. There...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
SAGE Publications
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3063420/ https://ncbi.nlm.nih.gov/pubmed/21442024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601910395582 |
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